Jason Koumas scored on his 300th league appearance to snatch an unlikely point for a below-par Wigan.
On 11 minutes, Clint Dempsey got on to the end of a Diomansy Kamara cross and fired home to put Fulham ahead.
Wigan had already been rocked two minutes earlier when striker Emile Heskey was forced off injured.
After the break, Chris Kirkland saved well to deny Dempsey before Koumas confidently slotted home a penalty after Mario Melchiot had been fouled.
It secured a barely-deserved draw for Wigan, who huffed and puffed and also lived dangerously as Fulham made the better of the chances.
The excellent Sebastian Larsson clipped in a pin-point cross for the unmarked Kapo, who stretched to poke home.
Bowyer opened the scoring after the restart when he picked up Carlton Cole’s ball and fired in a low volley.
Light. Prior to kick off they paid their respects to 1973 FA Cup-winning scorer Ian Porterfield, who died on Tuesday.
Reina dived low to his right to save Kanu’s penalty, after Alvaro Arbeloa had tugged the Nigerian’s shirt.
The home side and United were closely matched until Vidic arrived at the near post to power home Nani’s corner after 83 minutes to seal a crucial win.
Gareth Bale curled in a 15th minute free-kick to put Spurs ahead before Paul Robinson twice denied Adebayor.